Genetically Engineered Mouse Core

Overview of Services

The genetically engineered mouse (GEM) Core at Baylor College of Medicine (BCM) is a central core facility that helps BCM and other institution’s collaborative researchers to generate, rederive, import/Export and store all kinds of GEM lines. Our high quality services include ES cell microinjection to generate chimeric founder mice, DNA microinjection to generate transgenic mice, CRISPR/Cas9 (mRNA/DNA/protein) microinjection to edit the mouse genome, in vitro fertilization (IVF), cryopreservation of mouse embryo and sperm, and mouse line rederivation from fresh/frozen embryos or sperms.

 

The GEM Core possesses advanced technology, adequate animal resources and expensive equipment to provide high quality services for producing GEM models, allowing researchers to focus their efforts on the molecular and physiologic analysis of their mouse models.

 

Services offered by GEM Core:

  • Generation of Transgenic Mice by DNA Microinjection (Traditional, BAC and Lentiviral) (MDNA)
  • Mouse Embryonic Stem Cell Microinjection (ESCI) and (ABC57ESCI)
  • Mouse Embryo Cryopreservation (CRYO)
  • Rederivation of Mouse Lines (TMCR)
  • Mouse Colony Expansion (CE)
  • Mouse Sperm Cryopreservation (SPERQC)
  • In vitro Fertilization (IVF)
  • CRISPR/Cas9 (RNA/DNA/protein)
  • Storage of Cryopreserved Embryos/Sperm

Service prices

Please refer to the GEM Core Website:

https://www.bcm.edu/research/advanced-technology-core-labs/lab-listing/genetically-engineered-mouse/pricing

Leadership

Jianming Xu, Ph.D.
Professor
Academic Director
Email: jxu@bcm.edu
Office: 713-798-6199
Lab:713-798-4684

Lan Liao
Instuctor
Technical Director
Email: lliao@bcm.edu
Office: 713-798-5278
Lab: 713-798-4684

Location & Hours of Operation

 Hours of Operation Location

9am to 5pm
Monday - Friday

 Baylor College of Medicine
 Alkek Building N630
 Houston, Texas 77030

Links & Resources

  1. Transgenic Animal Web
  2. Oxford University Bioinformatics Centre

Contacts

Name Role Phone Email Location
Lan Liao
Technical Director
 
713-798-5278
 
lliao@bcm.edu
 
N603.01
 
Jianming Xu, Ph.D.
Academic Director
 
713-798-6199
 
jxu@bcm.edu
 
N630.03
 
Internal BCM iLab Support
Internal BCM iLab Support
 

 
ilabs-support@bcm.edu